› 2c10

X-ray diffraction
2.5Å resolution

The structure of a truncated, soluble version of semicarbazide- sensitive amine oxidase

Released:
DOI: 10.2210/pdb2c10/pdb
PDB entry 2c10 coloured by chain, front view.
PDB entry 2c10 coloured by chain, side view.
PDB entry 2c10 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1.
Jakobsson E, Nilsson J, Ogg D, Kleywegt GJ
Acta Crystallogr D Biol Crystallogr 61 1550-62 (2005)
PMID: 16239734

Function and Biology Details

Reaction catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Amine oxidase [copper-containing] 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 735 amino acids
Theoretical weight: 81.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16853 (Residues: 29-763; Coverage: 96%)
Gene names: AOC3, VAP1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
4 bound ligands:
Ligand NAG 8 x NAG
Ligand CA 8 x CA
Ligand CU 4 x CU
Ligand CL 8 x CL
1 modified residue:
Ligand TPQ 4 x TPQ

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P43
Unit cell:
a: 130.236Å b: 130.236Å c: 221.529Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.252
Expression system: Homo sapiens

Quick links

Citations

7 review citations

VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation.
Jalkanen et al. (2008)
6 more

45 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
44 more