› 2c30

X-ray diffraction
1.6Å resolution

Crystal Structure Of The Human P21-Activated Kinase 6

Released:
DOI: 10.2210/pdb2c30/pdb
PDB entry 2c30 coloured by chain, front view.
PDB entry 2c30 coloured by chain, side view.
PDB entry 2c30 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
Eswaran J, Lee WH, Debreczeni JE, Filippakopoulos P, Turnbull A, Fedorov O, Deacon SW, Peterson JR, Knapp S
Structure 15 201-13 (2007)
PMID: 17292838

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 6 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 36.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQU5 (Residues: 383-681; Coverage: 44%)
Gene names: PAK5, PAK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand CL 1 x CL
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 59.781Å b: 66.674Å c: 96.999Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.222
Expression system: Escherichia coli

Quick links

Citations

21 review citations

A tale of two Paks.
Arias-Romero et al. (2008)
20 more

12 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
11 more