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Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

X-ray diffraction
2.2Å resolution
PDB entry 2c7v coloured by chain, front view.
PDB entry 2c7v coloured by chain, side view.
PDB entry 2c7v coloured by chain, top view.
Source organism: Trypanosoma brucei brucei
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pteridine reductase
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Multimeric state: homo tetramer
Accessible surface area: 33130.72 Å2
Buried surface area: 24822.57 Å2
Dissociation area: 176.69 Å2
Dissociation energy (ΔGdiss): 20.44 kcal/mol
Dissociation entropy (TΔSdiss): -0.23 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131227

Macromolecules

Pteridine reductase
Chains: A, B, C, D
Length: 268 amino acids
Theoretical weight: 28.74 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O76290 (Residues: 1-268; Coverage: 100%)
Gene name: PTR1
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
Pteridine reductase in PDB entry 2c7v, assembly 1, front view.
Pteridine reductase in PDB entry 2c7v, assembly 1, side view.
Pteridine reductase in PDB entry 2c7v, assembly 1, top view.
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