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Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

Source organism: Trypanosoma brucei brucei
Biochemical function: pteridine reductase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.5.1.33: Pteridine reductase

Reaction catalysed:
5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 NADPH
Systematic name:
5,6,7,8-tetrahydrobiopterin:NADP(+) oxidoreductase
Alternative Name(s):
  • PTR1
  • Pteridine reductase 1

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. Pteridine reductase
The deposited structure of PDB entry 2c7v contains 4 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in Pteridine reductase. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. Pteridine reductase
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. Pteridine reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Pteridine reductase
IPR014058
Domain description: Pteridine reductase
Occurring in:
  1. Pteridine reductase

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Pteridine reductase
The deposited structure of PDB entry 2c7v contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in Pteridine reductase. Showing 1 copy in chain C.

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