› 2c7w

X-ray diffraction
2.48Å resolution

Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity

Released:
DOI: 10.2210/pdb2c7w/pdb
PDB entry 2c7w coloured by chain, front view.
PDB entry 2c7w coloured by chain, side view.
PDB entry 2c7w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding.
Iyer S, Scotney PD, Nash AD, Ravi Acharya K
J Mol Biol 359 76-85 (2006)
PMID: 16616187

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor B Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 11.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49765 (Residues: 31-129; Coverage: 53%)
Gene names: VEGFB, VRF
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P64
Unit cell:
a: 120.806Å b: 120.806Å c: 39.826Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.286 0.286 0.31
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Vascular endothelial growth factor (VEGF) signaling in tumor progression.
Roskoski R. (2007)
4 more

8 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
7 more