› 2car

X-ray diffraction
1.09Å resolution

Crystal Structure Of Human Inosine Triphosphatase

Released:
DOI: 10.2210/pdb2car/pdb
PDB entry 2car coloured by chain, front view.
PDB entry 2car coloured by chain, side view.
PDB entry 2car coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.
Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H
J Biol Chem 282 3182-7 (2007)
PMID: 17138556

Function and Biology Details

Reaction catalysed: 
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine triphosphate pyrophosphatase Chains: A, B
Molecule details ›
Chains: A, B
Length: 196 amino acids
Theoretical weight: 21.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BY32 (Residues: 1-194; Coverage: 100%)
Gene names: C20orf37, ITPA, My049, OK/SW-cl.9
Sequence domains: Ham1 family
Structure domains: Maf protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 31.23Å b: 105Å c: 50.14Å
α: 90° β: 90.01° γ: 90°
R-values:
R R work R free
0.097 not available 0.153
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Pharmacogenetic significance of inosine triphosphatase.
Bierau et al. (2007)
9 more

10 mentions without citation

ITPA (inosine triphosphate pyrophosphatase): from surveillance of nucleotide pools to human disease and pharmacogenetics.
Simone et al. (2013)
9 more