› 2cf2

X-ray diffraction
4.3Å resolution

Architecture of mammalian fatty acid synthase

Released:
DOI: 10.2210/pdb2cf2/pdb
PDB entry 2cf2 coloured by chain, front view.
PDB entry 2cf2 coloured by chain, side view.
PDB entry 2cf2 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Architecture of mammalian fatty acid synthase at 4.5 A resolution.
Maier T, Jenni S, Ban N
Science 311 1258-62 (2006)
PMID: 16513975

Function and Biology Details

Reaction catalysed: 
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141813 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
3-oxoacyl-[acyl-carrier-protein] synthase 1 Chains: A, J
Molecule details ›
Chains: A, J
Length: 406 amino acids
Theoretical weight: 42.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P0A953 (Residues: 1-406; Coverage: 100%)
Gene names: JW2320, b2323, fabB, fabC
Sequence domains:
FATTY ACID SYNTHASE, MAT DOMAIN Chains: B, K
Molecule details ›
Chains: B, K
Length: 304 amino acids
Theoretical weight: 30.98 KDa
Source organism: Sus scrofa
FATTY ACID SYNTHASE, DH DOMAIN Chains: C, L
Molecule details ›
Chains: C, L
Length: 342 amino acids
Theoretical weight: 37.7 KDa
Source organism: Sus scrofa
FATTY ACID SYNTHASE, ER DOMAIN Chains: D, M
Molecule details ›
Chains: D, M
Length: 295 amino acids
Theoretical weight: 31.51 KDa
Source organism: Sus scrofa
FATTY ACID SYNTHASE, KR DOMAIN Chains: E, N
Molecule details ›
Chains: E, N
Length: 226 amino acids
Theoretical weight: 23.7 KDa
Source organism: Sus scrofa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 96.1Å b: 245Å c: 134.1Å
α: 90° β: 101.2° γ: 90°

Quick links

Citations

62 review citations

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.
Menendez et al. (2007)
61 more

3 mentions without citation

Analysis of proteins with the 'hot dog' fold: prediction of function and identification of catalytic residues of hypothetical proteins.
Pidugu et al. (2009)
2 more