› 2cfv

X-ray diffraction
2.5Å resolution

Crystal structure of human protein tyrosine phosphatase receptor type J

Released:
DOI: 10.2210/pdb2cfv/pdb
PDB entry 2cfv coloured by chain, front view.
PDB entry 2cfv coloured by chain, side view.
PDB entry 2cfv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171436 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase eta Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12913 (Residues: 1016-1311; Coverage: 23%)
Gene names: DEP1, PTPRJ
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
Ligand NI 4 x NI
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 86.06Å b: 86.06Å c: 119.54Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.201 0.25
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

3 mentions without citation

Protein crystallization screens developed at the MRC Laboratory of Molecular Biology.
Gorrec F. (2016)
2 more