› 2ckk

X-ray diffraction
1.45Å resolution

High resolution crystal structure of the human kin17 C-terminal domain containing a kow motif

Released:
DOI: 10.2210/pdb2ckk/pdb
PDB entry 2ckk coloured by chain, front view.
PDB entry 2ckk coloured by chain, side view.
PDB entry 2ckk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics.
le Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J, Moutiez M, Gondry M, Angulo JF, Zinn-Justin S
J. Mol. Biol. 364 764-76 (2006)
PMID: 17045609

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA/RNA-binding protein KIN17 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60870 (Residues: 268-393; Coverage: 32%)
Gene names: BTCD, KIN, KIN17
Sequence domains: KN17 SH3-like C-terminal domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IOD 12 x IOD
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 45.752Å b: 46.309Å c: 60.798Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.139 0.137 0.175
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Roles and regulatory mechanisms of KIN17 in cancers (Review).
Huang et al. (2023)
12 other articles

3 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
2 more