› 2cml

X-ray diffraction
2.15Å resolution

Structure of Neuraminidase from English Duck Subtype N6 Complexed with 30 MM ZANAMIVIR, Crystal Soaked for 3 Hours at 291 K.

Released:
DOI: 10.2210/pdb2cml/pdb
PDB entry 2cml coloured by chain, front view.
PDB entry 2cml coloured by chain, side view.
PDB entry 2cml coloured by chain, top view.
Source organism: Influenza A virus
Entry authors: Rudino-Pinera E, Tunnah P, Lukacik P, Crennell SJ, Webster RG, Laver WG, Garman EF

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Neuraminidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 389 amino acids
Theoretical weight: 43.01 KDa
Source organism: Influenza A virus
Expression system: Gallus gallus
UniProt:
  • Canonical: Q6XV27 (Residues: 82-470; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN
Carbohydrate polymer
5 bound ligands:
Ligand ZMR 8 x ZMR
Ligand CA 4 x CA
Ligand NAG 11 x NAG
Ligand BMA 3 x BMA
Ligand MAN 8 x MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200H
Spacegroup: P21
Unit cell:
a: 106.241Å b: 73.685Å c: 106.684Å
α: 90° β: 90.29° γ: 90°
R-values:
R R work R free
0.183 0.18 0.232
Expression system: Gallus gallus

Quick links