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Crystal structure of the CDC42-Collybistin II complex

X-ray diffraction
2.15Å resolution
PDB entry 2dfk coloured by chain, front view.
PDB entry 2dfk coloured by chain, side view.
PDB entry 2dfk coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Rho guanine nucleotide exchange factor 9 and Cell division control protein 42 homolog
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Multimeric state: hetero dimer
Accessible surface area: 29180.71 Å2
Buried surface area: 4015.88 Å2
Dissociation area: 1,504.72 Å2
Dissociation energy (ΔGdiss): 13.85 kcal/mol
Dissociation entropy (TΔSdiss): 13.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158146
Assembly 2 (preferred)
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Assembly Name: Rho guanine nucleotide exchange factor 9 and Cell division control protein 42 homolog
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Multimeric state: hetero dimer
Accessible surface area: 27060.31 Å2
Buried surface area: 3911.49 Å2
Dissociation area: 1,651.04 Å2
Dissociation energy (ΔGdiss): 12.62 kcal/mol
Dissociation entropy (TΔSdiss): 13.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158146
Assembly 3
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Assembly Name: Rho guanine nucleotide exchange factor 9 and Cell division control protein 42 homolog
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Multimeric state: hetero tetramer
Accessible surface area: 53245.39 Å2
Buried surface area: 10923.0 Å2
Dissociation area: 1,498.96 Å2
Dissociation energy (ΔGdiss): 3.26 kcal/mol
Dissociation entropy (TΔSdiss): 14.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158156

Macromolecules

Rho guanine nucleotide exchange factor 9
Chains: A, C
Length: 402 amino acids
Theoretical weight: 48.25 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QX73 (Residues: 71-463; Coverage: 80%)
Gene name: Arhgef9
Pfam:
InterPro:
CATH:
SCOP:
Rho guanine nucleotide exchange factor 9 in PDB entry 2dfk, assembly 2, front view.
Rho guanine nucleotide exchange factor 9 in PDB entry 2dfk, assembly 2, side view.
Rho guanine nucleotide exchange factor 9 in PDB entry 2dfk, assembly 2, top view.
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Cell division control protein 42 homolog
Chains: B, D
Length: 194 amino acids
Theoretical weight: 21.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60953 (Residues: 1-191; Coverage: 100%)
Gene name: CDC42
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
Cell division control protein 42 homolog in PDB entry 2dfk, assembly 2, front view.
Cell division control protein 42 homolog in PDB entry 2dfk, assembly 2, side view.
Cell division control protein 42 homolog in PDB entry 2dfk, assembly 2, top view.
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