EC 3.6.5.2: Small monomeric GTPase
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)
GO terms
Biochemical function:
- ubiquitin protein ligase activity
- identical protein binding
- apolipoprotein A-I receptor binding
- GBD domain binding
- thioesterase binding
- mitogen-activated protein kinase kinase kinase binding
- GTP-dependent protein binding
- protein kinase binding
- hydrolase activity
- GTP binding
- protein binding
- G protein activity
- GTPase activity
- nucleotide binding
- guanyl-nucleotide exchange factor activity
Biological process:
- positive regulation of substrate adhesion-dependent cell spreading
- modification of synaptic structure
- regulation of postsynapse organization
- regulation of modification of postsynaptic structure
- positive regulation of intracellular protein transport
- actin filament branching
- endothelin receptor signaling pathway involved in heart process
- organelle transport along microtubule
- cellular response to type II interferon
- dendritic spine morphogenesis
- submandibular salivary gland formation
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- Wnt signaling pathway, planar cell polarity pathway
- heart contraction
- regulation of attachment of spindle microtubules to kinetochore
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of synapse structural plasticity
- establishment of Golgi localization
- establishment of localization in cell
- nucleus localization
- positive regulation of stress fiber assembly
- regulation of stress fiber assembly
- positive regulation of filopodium assembly
- regulation of filopodium assembly
- positive regulation of cellular component organization
- neuron fate determination
- positive regulation of pinocytosis
- filopodium assembly
- positive regulation of JNK cascade
- positive regulation of DNA replication
- establishment of epithelial cell apical/basal polarity
- modulation by host of viral process
- positive regulation of neuron apoptotic process
- positive regulation of MAPK cascade
- neuropilin signaling pathway
- dendritic cell migration
- establishment or maintenance of apical/basal cell polarity
- embryonic heart tube development
- adherens junction organization
- cell junction assembly
- regulation of actin cytoskeleton organization
- Cdc42 protein signal transduction
- positive regulation of cytokinesis
- negative regulation of protein-containing complex assembly
- positive regulation of pseudopodium assembly
- positive regulation of cell migration
- positive regulation of cell growth
- macrophage differentiation
- cell differentiation
- actin cytoskeleton organization
- substantia nigra development
- positive regulation of lamellipodium assembly
- regulation of lamellipodium assembly
- anatomical structure morphogenesis
- protein localization
- nervous system development
- small GTPase-mediated signal transduction
- integrin-mediated signaling pathway
- establishment or maintenance of cell polarity
- nuclear migration
- regulation of mitotic nuclear division
- Golgi organization
- actin filament organization
- phagocytosis, engulfment
- endocytosis
- cardiac neural crest cell migration involved in outflow tract morphogenesis
- cardiac conduction system development
- heart process
- sprouting angiogenesis
Cellular component:
- glutamatergic synapse
- Schaffer collateral - CA1 synapse
- mitotic spindle
- cell periphery
- extracellular exosome
- spindle midzone
- phagocytic vesicle
- apical part of cell
- membrane-bounded organelle
- dendritic spine
- neuronal cell body
- neuron projection
- cell projection
- cytoplasmic ribonucleoprotein granule
- protein-containing complex
- leading edge membrane
- cell leading edge
- midbody
- dendrite
- filopodium
- secretory granule
- Golgi transport complex
- membrane
- focal adhesion
- cell-cell junction
- plasma membrane
- cytoskeleton
- cytosol
- spindle
- centrosome
- endoplasmic reticulum membrane
- cytoplasm
- storage vacuole
- Golgi membrane
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.40.50.300
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
P-loop containing nucleotide triphosphate hydrolases
Occurring in:
2.30.29.30
Class:
Mainly Beta
Architecture:
Roll
Topology:
PH-domain like
Homology:
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
SCOP annotations
52592
Class:
Alpha and beta proteins (a/b)
Fold:
P-loop containing nucleoside triphosphate hydrolases
Superfamily:
P-loop containing nucleoside triphosphate hydrolases
Occurring in:
50730
Class:
All beta proteins
Fold:
PH domain-like barrel
Superfamily:
PH domain-like
Occurring in:
48066
Class:
All alpha proteins
Fold:
DBL homology domain (DH-domain)
Superfamily:
DBL homology domain (DH-domain)
Occurring in:
