› 2dwy

X-ray diffraction
2.3Å resolution

Crystal Structure Analysis of GGA1-GAE

Released:
DOI: 10.2210/pdb2dwy/pdb
PDB entry 2dwy coloured by chain, front view.
PDB entry 2dwy coloured by chain, side view.
PDB entry 2dwy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1.
Inoue M, Shiba T, Ihara K, Yamada Y, Hirano S, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Nakayama K, Wakatsuki S
Traffic 8 904-13 (2007)
PMID: 17506864

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-193827 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosylation factor-binding protein GGA1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 133 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UJY5 (Residues: 507-639; Coverage: 21%)
Gene name: GGA1
Sequence domains: Adaptin C-terminal domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21
Unit cell:
a: 47.482Å b: 88.238Å c: 67.224Å
α: 90° β: 96.1° γ: 90°
R-values:
R R work R free
0.219 0.217 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Survey of the year 2007 commercial optical biosensor literature.
Rich et al. (2008)
1 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)