› 2e6w

Solution NMR

Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin

Released:
DOI: 10.2210/pdb2e6w/pdb
PDB entry 2e6w coloured by chain, front view.
PDB entry 2e6w coloured by chain, side view.
PDB entry 2e6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin.
Yu L, Sun C, Mendoza R, Wang J, Matayoshi ED, Hebert E, Pereda-Lopez A, Hajduk PJ, Olejniczak ET
Protein Sci 16 2502-9 (2007)
PMID: 17962406

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195171 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calsenilin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y2W7 (Residues: 161-256; Coverage: 38%)
Gene names: CSEN, DREAM, KCHIP3, KCNIP3
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function.
Getty et al. (2011)
1 more

5 mentions without citation

Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs.
Cercós et al. (2021)
4 more