› 2ec7

Solution NMR

Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein

Released:
DOI: 10.2210/pdb2ec7/pdb
PDB entry 2ec7 coloured by chain, ensemble of 11 models, front view.
PDB entry 2ec7 coloured by chain, ensemble of 11 models, side view.
PDB entry 2ec7 coloured by chain, ensemble of 11 models, top view.
Source organism: Human immunodeficiency virus type 2 (ISOLATE GHANA-1)
Primary publication:
The RNA recognition mechanism of human immunodeficiency virus (HIV) type 2 NCp8 is different from that of HIV-1 NCp7.
Matsui T, Tanaka T, Endoh H, Sato K, Tanaka H, Miyauchi E, Kawashima Y, Nagai-Makabe M, Komatsu H, Kohno T, Maeda T, Kodera Y
Biochemistry 48 4314-23 (2009)
PMID: 19334676

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148270 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleocapsid protein p7 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.57 KDa
Source organism: Human immunodeficiency virus type 2 (ISOLATE GHANA-1)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18041 (Residues: 384-432; Coverage: 9%)
Gene name: gag
Sequence domains: Zinc knuckle
Structure domains: Zinc finger, CCHC-type

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

New insights into HTLV-1 particle structure, assembly, and Gag-Gag interactions in living cells.
Fogarty et al. (2011)
1 more

1 mention without citation

Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication.
Rawson et al. (2022)