› 2ec8

X-ray diffraction
3Å resolution

Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit

Released:
DOI: 10.2210/pdb2ec8/pdb
PDB entry 2ec8 coloured by chain, front view.
PDB entry 2ec8 coloured by chain, side view.
PDB entry 2ec8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.
Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J
Cell 130 323-34 (2007)
PMID: 17662946

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 524 amino acids
Theoretical weight: 59.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10721 (Residues: 1-519; Coverage: 52%)
Gene names: KIT, SCFR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: R3
Unit cell:
a: 162.249Å b: 162.249Å c: 67.586Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.254 0.295
Expression system: Spodoptera frugiperda

Quick links

Citations

59 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
58 more

9 mentions without citation

More than the sum of the parts: Toward full-length receptor tyrosine kinase structures.
Diwanji et al. (2019)
8 more