› 2enq

Solution NMR

Solution structure of the C2 domain from human PI3-kinase p110 subunit alpha

Released:
DOI: 10.2210/pdb2enq/pdb
PDB entry 2enq coloured by chain, ensemble of 20 models, front view.
PDB entry 2enq coloured by chain, ensemble of 20 models, side view.
PDB entry 2enq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Endo H, Nagashima T, Yoshida M, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42336 (Residues: 331-481; Coverage: 14%)
Gene name: PIK3CA
Sequence domains: Phosphoinositide 3-kinase C2
Structure domains: C2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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