› 2es0

X-ray diffraction
2.1Å resolution

Structure of the regulator of G-protein signaling domain of RGS6

Released:
DOI: 10.2210/pdb2es0/pdb
PDB entry 2es0 coloured by chain, front view.
PDB entry 2es0 coloured by chain, side view.
PDB entry 2es0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP
Proc Natl Acad Sci U S A 105 6457-62 (2008)
PMID: 18434541

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 6 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 17.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49758 (Residues: 325-470; Coverage: 31%)
Gene name: RGS6
Sequence domains: Regulator of G protein signaling domain
Structure domains: Regulator of G-protein Signalling 4, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 77.567Å b: 77.567Å c: 73.02Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.195 0.229
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Update on melatonin receptors: IUPHAR Review 20.
Jockers et al. (2016)
22 more

4 mentions without citation

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Vedadi et al. (2006)
3 more