› 2esg

X-ray solution scattering

Solution structure of the complex between immunoglobulin IgA1 and human serum albumin

Released:
DOI: 10.2210/pdb2esg/pdb
PDB entry 2esg coloured by chain, front view.
PDB entry 2esg coloured by chain, side view.
PDB entry 2esg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Purification, properties and extended solution structure of the complex formed between human immunoglobulin A1 and human serum albumin by scattering and ultracentrifugation.
Almogren A, Furtado PB, Sun Z, Perkins SJ, Kerr MA
J Mol Biol 356 413-31 (2006)
PMID: 16376934

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-208684 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin A1 light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 214 amino acids
Theoretical weight: 23.22 KDa
Source organism: Homo sapiens
Immunoglobulin heavy constant alpha 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 475 amino acids
Theoretical weight: 51.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01876 (Residues: 1-333; Coverage: 84%)
Gene name: IGHA1
Sequence domains:
Albumin Chain: C
Molecule details ›
Chain: C
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Spacegroup: P1
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Fatty acid binding to serum albumin: molecular simulation approaches.
Fujiwara et al. (2013)
2 more

3 mentions without citation

Proteomic and molecular dynamic investigations of PTM-induced structural fluctuations in breast and ovarian cancer.
Tikhonov et al. (2021)
2 more