› 2exx

X-ray diffraction
2.4Å resolution

Crystal structure of HSCARG from Homo sapiens in complex with NADP

Released:
DOI: 10.2210/pdb2exx/pdb
PDB entry 2exx coloured by chain, front view.
PDB entry 2exx coloured by chain, side view.
PDB entry 2exx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein.
Zheng X, Dai X, Zhao Y, Chen Q, Lu F, Yao D, Yu Q, Liu X, Zhang C, Gu X, Luo M
Proc Natl Acad Sci U S A 104 8809-14 (2007)
PMID: 17496144

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NmrA-like family domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 34.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HBL8 (Residues: 1-299; Coverage: 100%)
Gene names: HSCARG, NMRAL1
Sequence domains: NmrA-like family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAP 1 x NAP
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: F23
Unit cell:
a: 223.3Å b: 223.3Å c: 223.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.233 0.265
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
Kavanagh et al. (2008)
6 more

5 mentions without citation

Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein.
Zheng et al. (2007)
4 more