› 2f34

X-ray diffraction
1.74Å resolution

Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution

Released:
DOI: 10.2210/pdb2f34/pdb
PDB entry 2f34 coloured by chain, front view.
PDB entry 2f34 coloured by chain, side view.
PDB entry 2f34 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Mayer ML, Ghosal A, Dolman NP, Jane DE
J Neurosci 26 2852-61 (2006)
PMID: 16540562

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-149793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 446-559, 682-821; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand 1PE 2 x 1PE
Ligand UBA 2 x UBA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 97.698Å b: 97.954Å c: 129.126Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.211
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
9 more

11 mentions without citation

Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Mayer et al. (2006)
10 more