› 2f37

X-ray diffraction
1.7Å resolution

Crystal structure of the ankyrin repeat domain of human TRPV2

Released:
DOI: 10.2210/pdb2f37/pdb
PDB entry 2f37 coloured by chain, front view.
PDB entry 2f37 coloured by chain, side view.
PDB entry 2f37 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human TRPV2 channel ankyrin repeat domain.
McCleverty CJ, Koesema E, Patapoutian A, Lesley SA, Kreusch A
Protein Sci 15 2201-6 (2006)
PMID: 16882997

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195285 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 27.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5S1 (Residues: 69-319; Coverage: 33%)
Gene names: TRPV2, VRL
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P6122
Unit cell:
a: 93.657Å b: 93.657Å c: 265.855Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.207 0.229
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Molecular mechanism of TRP channels.
Zheng J. (2013)
19 more

6 mentions without citation

A primer on ankyrin repeat function in TRP channels and beyond.
Gaudet R. (2008)
5 more