› 2f9q

X-ray diffraction
3Å resolution

Crystal Structure of Human Cytochrome P450 2D6

Released:
DOI: 10.2210/pdb2f9q/pdb
PDB entry 2f9q coloured by chain, front view.
PDB entry 2f9q coloured by chain, side view.
PDB entry 2f9q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human cytochrome P450 2D6.
Rowland P, Blaney FE, Smyth MG, Jones JJ, Leydon VR, Oxbrow AK, Lewis CJ, Tennant MG, Modi S, Eggleston DS, Chenery RJ, Bridges AM
J Biol Chem 281 7614-22 (2006)
PMID: 16352597

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145369 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2D6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 479 amino acids
Theoretical weight: 53.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10635 (Residues: 34-497; Coverage: 93%)
Gene names: CYP2D6, CYP2DL1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:
Ligand HEM 4 x HEM
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 145.066Å b: 155.495Å c: 95.801Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.286
Expression system: Escherichia coli

Quick links

Citations

47 review citations

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
Zanger et al. (2013)
46 more

60 mentions without citation

Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis
Elfaki et al. (2018)
59 more