› 2fma

X-ray diffraction
0.85Å resolution

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution

Released:
DOI: 10.2210/pdb2fma/pdb
PDB entry 2fma coloured by chain, front view.
PDB entry 2fma coloured by chain, side view.
PDB entry 2fma coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Kong GK, Adams JJ, Cappai R, Parker MW
Acta Crystallogr Sect F Struct Biol Cryst Commun 63 819-24 (2007)
PMID: 17909280

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.85 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 133-189; Coverage: 8%)
Gene names: A4, AD1, APP
Sequence domains: Copper-binding of amyloid precursor, CuBD
Structure domains: Amyloidogenic glycoprotein, copper-binding domain

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 31.289Å b: 32.488Å c: 50.088Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.13 0.13 0.15
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Copper in the brain and Alzheimer's disease.
Hung et al. (2010)
1 more

11 mentions without citation

Copper binding to the Alzheimer's disease amyloid precursor protein.
Kong et al. (2008)
10 more