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Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen

X-ray diffraction
3.1Å resolution
PDB entry 2fse coloured by chain, front view.
PDB entry 2fse coloured by chain, side view.
PDB entry 2fse coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 18081.63 Å2
Buried surface area: 6911.71 Å2
Dissociation area: 1,077.32 Å2
Dissociation energy (ΔGdiss): 10.29 kcal/mol
Dissociation entropy (TΔSdiss): 8.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135306
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 17932.48 Å2
Buried surface area: 7068.52 Å2
Dissociation area: 1,056.66 Å2
Dissociation energy (ΔGdiss): 6.61 kcal/mol
Dissociation entropy (TΔSdiss): 8.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135306

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, C
Length: 178 amino acids
Theoretical weight: 20.71 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 29-206; Coverage: 78%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 2fse, assembly 2, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 2fse, assembly 2, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 2fse, assembly 2, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, D
Length: 187 amino acids
Theoretical weight: 21.91 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01911 (Residues: 33-219; Coverage: 79%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 2fse, assembly 2, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 2fse, assembly 2, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 2fse, assembly 2, top view.
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Collagen alpha-1(II) chain
Chains: E, F
Length: 14 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P02458 (Residues: 461-474; Coverage: 1%)
Gene name: COL2A1
Collagen alpha-1(II) chain in PDB entry 2fse, assembly 2, front view.
Collagen alpha-1(II) chain in PDB entry 2fse, assembly 2, side view.
Collagen alpha-1(II) chain in PDB entry 2fse, assembly 2, top view.
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