› 2fse

X-ray diffraction
3.1Å resolution

Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen

Released:
DOI: 10.2210/pdb2fse/pdb
PDB entry 2fse coloured by chain, front view.
PDB entry 2fse coloured by chain, side view.
PDB entry 2fse coloured by chain, top view.
Source organisms:
Primary publication:
Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen.
Rosloniec EF, Ivey RA, Whittington KB, Kang AH, Park HW
J Immunol 177 3884-92 (2006)
PMID: 16951351

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135306 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 178 amino acids
Theoretical weight: 20.71 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 29-206; Coverage: 78%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 187 amino acids
Theoretical weight: 21.91 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01911 (Residues: 33-219; Coverage: 79%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
Collagen alpha-1(II) chain Chains: E, F
Molecule details ›
Chains: E, F
Length: 14 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P02458 (Residues: 461-474; Coverage: 1%)
Gene name: COL2A1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 60.81Å b: 109Å c: 170.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.295
Expression system: Drosophila melanogaster

Quick links

Citations

2 review citations

The immunopathogenesis of rheumatoid arthritis.
Imboden JB. (2009)
1 more

43 mentions without citation

Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.
Painter et al. (2012)
42 more