› 2fsz

X-ray diffraction
2.2Å resolution

A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta

Released:
DOI: 10.2210/pdb2fsz/pdb
PDB entry 2fsz coloured by chain, front view.
PDB entry 2fsz coloured by chain, side view.
PDB entry 2fsz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.
Wang Y, Chirgadze NY, Briggs SL, Khan S, Jensen EV, Burris TP
Proc Natl Acad Sci U S A 103 9908-11 (2006)
PMID: 16782818

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-187733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 27.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92731 (Residues: 257-502; Coverage: 46%)
Gene names: ESR2, ESTRB, NR3A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand OHT 4 x OHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I4
Unit cell:
a: 105.04Å b: 105.04Å c: 102.391Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.274 0.273 0.299
Expression system: Escherichia coli BL21(DE3)

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Citations

14 review citations

Estrogen receptors: how do they signal and what are their targets.
Heldring et al. (2007)
13 more

13 mentions without citation

A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.
Wang et al. (2006)
12 more