› 2ftc

Electron Microscopy
12.1Å resolution

Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome

Released:
DOI: 10.2210/pdb2ftc/pdb
PDB entry 2ftc coloured by chain, front view.
PDB entry 2ftc coloured by chain, side view.
PDB entry 2ftc coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
A structural model for the large subunit of the mammalian mitochondrial ribosome.
Mears JA, Sharma MR, Gutell RR, McCook AS, Richardson PE, Caulfield TR, Agrawal RK, Harvey SC
J Mol Biol 358 193-212 (2006)
PMID: 16510155

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108023 (preferred)
Entry contents:
16 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (17 distinct):
Large ribosomal subunit protein uL1m Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.22 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: A6QPQ5 (Residues: 123-311; Coverage: 58%)
Gene name: MRPL1
Sequence domains: Ribosomal protein L1p/L10e family
Large ribosomal subunit protein uL2m Chain: B
Molecule details ›
Chain: B
Length: 136 amino acids
Theoretical weight: 14.44 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q2TA12 (Residues: 127-262; Coverage: 44%)
Gene name: MRPL2
Sequence domains:
Large ribosomal subunit protein uL3m Chain: C
Molecule details ›
Chain: C
Length: 211 amino acids
Theoretical weight: 23.4 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3ZBX6 (Residues: 96-306; Coverage: 61%)
Gene name: MRPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4m Chain: D
Molecule details ›
Chain: D
Length: 175 amino acids
Theoretical weight: 19.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q32PI6 (Residues: 97-271; Coverage: 60%)
Gene name: MRPL4
Sequence domains: Ribosomal protein L4/L1 family
Large ribosomal subunit protein bL12m Chains: E, F
Molecule details ›
Chains: E, F
Length: 137 amino acids
Theoretical weight: 14.83 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q7YR75 (Residues: 62-198; Coverage: 69%)
Gene name: MRPL12
Sequence domains:
Large ribosomal subunit protein uL11m Chain: G
Molecule details ›
Chain: G
Length: 145 amino acids
Theoretical weight: 15.61 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q2YDI0 (Residues: 13-157; Coverage: 76%)
Gene name: MRPL11
Sequence domains:
Large ribosomal subunit protein uL13m Chain: H
Molecule details ›
Chain: H
Length: 148 amino acids
Theoretical weight: 16.96 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3SYS1 (Residues: 1-148; Coverage: 83%)
Gene name: MRPL13
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL16m Chain: I
Molecule details ›
Chain: I
Length: 118 amino acids
Theoretical weight: 13.11 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3T0J3 (Residues: 71-188; Coverage: 47%)
Gene name: MRPL16
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein bL17m Chain: J
Molecule details ›
Chain: J
Length: 116 amino acids
Theoretical weight: 13.68 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3T0L3 (Residues: 11-127; Coverage: 67%)
Gene name: MRPL17
Sequence domains: Ribosomal protein L17
Large ribosomal subunit protein bL19m Chain: K
Molecule details ›
Chain: K
Length: 98 amino acids
Theoretical weight: 11.1 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q2HJI0 (Residues: 108-205; Coverage: 34%)
Gene name: MRPL19
Sequence domains: Ribosomal protein L19
Large ribosomal subunit protein bL20m Chain: L
Molecule details ›
Chain: L
Length: 118 amino acids
Theoretical weight: 14.13 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q2TBR2 (Residues: 8-124; Coverage: 79%)
Gene name: MRPL20
Sequence domains: Ribosomal protein L20
Large ribosomal subunit protein uL22m Chain: M
Molecule details ›
Chain: M
Length: 110 amino acids
Theoretical weight: 12.91 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3SZX5 (Residues: 67-176; Coverage: 54%)
Gene name: MRPL22
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL24m Chain: N
Molecule details ›
Chain: N
Length: 96 amino acids
Theoretical weight: 11.01 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3SYS0 (Residues: 59-154; Coverage: 44%)
Gene name: MRPL24
Sequence domains:
Large ribosomal subunit protein bL27m Chain: O
Molecule details ›
Chain: O
Length: 69 amino acids
Theoretical weight: 7.52 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q32PC3 (Residues: 31-99; Coverage: 47%)
Gene name: MRPL27
Sequence domains: Ribosomal L27 protein
Large ribosomal subunit protein bL33m Chain: P
Molecule details ›
Chain: P
Length: 52 amino acids
Theoretical weight: 6.09 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3SZ47 (Residues: 9-60; Coverage: 80%)
Gene name: MRPL33
Sequence domains: Ribosomal protein L33
Large ribosomal subunit protein bL34m Chain: Q
Molecule details ›
Chain: Q
Length: 38 amino acids
Theoretical weight: 4.49 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: A8NN94 (Residues: 57-94; Coverage: 40%)
Gene name: MRPL34
Sequence domains: Ribosomal protein L34
Mitochondrial 16S ribosomal RNA Chain: R
Molecule details ›
Chain: R
Length: 1568 nucleotides
Theoretical weight: 504.15 KDa
Sequence domains: Bacterial large subunit ribosomal RNA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 12.1Å

Quick links

Citations

18 review citations

A disproportionate role for mtDNA in Dobzhansky-Muller incompatibilities?
Burton et al. (2012)
17 more

5 mentions without citation

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases.
Shey et al. (2019)
4 more