› 2ftu

Solution NMR

solution structure of domain 3 of RAP

Released:
DOI: 10.2210/pdb2ftu/pdb
PDB entry 2ftu coloured by chain, ensemble of 20 models, front view.
PDB entry 2ftu coloured by chain, ensemble of 20 models, side view.
PDB entry 2ftu coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.
Lee D, Walsh JD, Mikhailenko I, Yu P, Migliorini M, Wu Y, Krueger S, Curtis JE, Harris B, Lockett S, Blacklow SC, Strickland DK, Wang YX
Mol Cell 22 423-30 (2006)
PMID: 16678114

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-2-macroglobulin receptor-associated protein Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30533 (Residues: 240-357; Coverage: 37%)
Gene names: A2MRAP, LRPAP1
Sequence domains: Alpha-2-macroglobulin RAP, C-terminal domain
Structure domains: RAP domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

8 review citations

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis et al. (2008)
7 more

1 mention without citation

Addressing the Role of Conformational Diversity in Protein Structure Prediction.
Palopoli et al. (2016)