› 2fxm

X-ray diffraction
2.7Å resolution

Structure of the human beta-myosin S2 fragment

Released:
DOI: 10.2210/pdb2fxm/pdb
PDB entry 2fxm coloured by chain, front view.
PDB entry 2fxm coloured by chain, side view.
PDB entry 2fxm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment.
Blankenfeldt W, Thomä NH, Wray JS, Gautel M, Schlichting I
Proc Natl Acad Sci U S A 103 17713-7 (2006)
PMID: 17095604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146366 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myosin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 15.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P12883 (Residues: 838-963; Coverage: 7%)
Gene names: MYH7, MYHCB
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

1 bound ligand:
Ligand HG 2 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2221
Unit cell:
a: 40.29Å b: 45.97Å c: 373.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.283
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.
Trivedi et al. (2018)
11 more

29 mentions without citation

Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.
Alamo et al. (2018)
28 more