› 2fxo

X-ray diffraction
2.5Å resolution

Structure of the human beta-myosin S2 fragment

Released:
DOI: 10.2210/pdb2fxo/pdb
PDB entry 2fxo coloured by chain, front view.
PDB entry 2fxo coloured by chain, side view.
PDB entry 2fxo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment.
Blankenfeldt W, Thomä NH, Wray JS, Gautel M, Schlichting I
Proc Natl Acad Sci U S A 103 17713-7 (2006)
PMID: 17095604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146366 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myosin-7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 129 amino acids
Theoretical weight: 15.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P12883 (Residues: 838-963; Coverage: 7%)
Gene names: MYH7, MYHCB
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P1
Unit cell:
a: 40.157Å b: 41.867Å c: 97.795Å
α: 91.11° β: 92.73° γ: 107.18°
R-values:
R R work R free
0.277 0.273 0.349
Expression system: Escherichia coli BL21

Quick links

Citations

13 review citations

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.
Trivedi et al. (2018)
12 more

10 mentions without citation

Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment.
Blankenfeldt et al. (2006)
9 more