› 2g2h

X-ray diffraction
2Å resolution

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Released:
DOI: 10.2210/pdb2g2h/pdb
PDB entry 2g2h coloured by chain, front view.
PDB entry 2g2h coloured by chain, side view.
PDB entry 2g2h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Src-like inactive conformation in the abl tyrosine kinase domain.
Levinson NM, Kuchment O, Shen K, Young MA, Koldobskiy M, Karplus M, Cole PA, Kuriyan J
PLoS Biol 4 e144 (2006)
PMID: 16640460

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 33.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00519 (Residues: 229-512; Coverage: 25%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand P16 2 x P16
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21212
Unit cell:
a: 104.386Å b: 131.487Å c: 56.499Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.213
Expression system: Escherichia coli

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Citations

34 review citations

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Strebhardt et al. (2008)
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12 mentions without citation

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
Cowan-Jacob et al. (2007)
11 more