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Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule

X-ray diffraction
2Å resolution
PDB entry 2g9h coloured by chain, front view.
PDB entry 2g9h coloured by chain, side view.
PDB entry 2g9h coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 27529.54 Å2
Buried surface area: 10074.58 Å2
Dissociation area: 1,394.13 Å2
Dissociation energy (ΔGdiss): 23.01 kcal/mol
Dissociation entropy (TΔSdiss): 8.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135321

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 2g9h, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 2g9h, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 2g9h, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 2g9h, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 2g9h, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 2g9h, assembly 1, top view.
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Hemagglutinin HA1 chain
Chain: C
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/England/878/1969(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P04664 (Residues: 306-318; Coverage: 4%)
Gene name: HA
Hemagglutinin HA1 chain in PDB entry 2g9h, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 2g9h, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 2g9h, assembly 1, top view.
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Enterotoxin type I
Chain: D
Length: 218 amino acids
Theoretical weight: 24.96 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: Q52T95 (Residues: 1-218; Coverage: 100%)
Pfam:
InterPro:
CATH:
SCOP:
Enterotoxin type I in PDB entry 2g9h, assembly 1, front view.
Enterotoxin type I in PDB entry 2g9h, assembly 1, side view.
Enterotoxin type I in PDB entry 2g9h, assembly 1, top view.
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