› › Function and Biology

Monomeric sarcosine oxidase: structure of a covalently flavinylated amine oxidizing enzyme

Source organism: Bacillus sp. B-0618
Biochemical function: saccharopine oxidase activity
Biological process: L-lysine catabolic process to acetyl-CoA via L-pipecolate
Cellular component: cytosol

Quick links

EC 1.5.3.1: Sarcosine oxidasee (formaldehyde-forming)

Reaction catalysed:
Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2)
Systematic name:
Sarcosine:oxygen oxidoreductase (demethylating)
Alternative Name(s):
  • MSOX
  • Monomeric sarcosine oxidase
  • Sarcosine oxidasee

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01266
Domain description: FAD dependent oxidoreductase
Occurring in:
  1. Monomeric sarcosine oxidase
The deposited structure of PDB entry 2gb0 contains 2 copies of Pfam domain PF01266 (FAD dependent oxidoreductase) in Monomeric sarcosine oxidase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Monomeric sarcosine oxidase
IPR006281
Domain description: Sarcosine oxidase, monomeric
Occurring in:
  1. Monomeric sarcosine oxidase
IPR006076
Domain description: FAD dependent oxidoreductase
Occurring in:
  1. Monomeric sarcosine oxidase
IPR045170
Domain description: MTOX family
Occurring in:
  1. Monomeric sarcosine oxidase

Structure domains

CATH CATH domains
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Monomeric sarcosine oxidase
The deposited structure of PDB entry 2gb0 contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Monomeric sarcosine oxidase. Showing 1 copy in chain B.
3.30.9.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-Amino Acid Oxidase; Chain A, domain 2
Homology: D-Amino Acid Oxidase, subunit A, domain 2
Occurring in:
  1. Monomeric sarcosine oxidase
The deposited structure of PDB entry 2gb0 contains 2 copies of CATH domain 3.30.9.10 (D-Amino Acid Oxidase; Chain A, domain 2) in Monomeric sarcosine oxidase. Showing 1 copy in chain B.
SCOP SCOP annotations
51913
Class: Alpha and beta proteins (a/b)
Fold: FAD/NAD(P)-binding domain
Superfamily: FAD/NAD(P)-binding domain
Occurring in:
  1. Monomeric sarcosine oxidase
The deposited structure of PDB entry 2gb0 contains 2 copies of SCOP domain 51913 (FAD-linked reductases, N-terminal domain) in Monomeric sarcosine oxidase. Showing 1 copy in chain B.
54384
Class: Alpha and beta proteins (a+b)
Fold: FAD-linked reductases, C-terminal domain
Superfamily: FAD-linked reductases, C-terminal domain
Occurring in:
  1. Monomeric sarcosine oxidase
The deposited structure of PDB entry 2gb0 contains 2 copies of SCOP domain 54384 (D-aminoacid oxidase-like) in Monomeric sarcosine oxidase. Showing 1 copy in chain B.

Quick links