Function and Biology Details
Reactions catalysed:
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)(+) = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (preferred)
PDBe Complex ID:
PDB-CPX-147362 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 29.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain
Length: 267 amino acids
Theoretical weight: 29.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P15428 (Residues: 3-256; Coverage: 96%)
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain
