› 2gf0

X-ray diffraction
1.9Å resolution

The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state

Released:
DOI: 10.2210/pdb2gf0/pdb
PDB entry 2gf0 coloured by chain, front view.
PDB entry 2gf0 coloured by chain, side view.
PDB entry 2gf0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Turnbull AP, Papagrigoriou E, Yang X, Schoch G, Elkins J, Gileadi O, Salah E, Bray J, Wen-Hwa L, Fedorov O, Niesen FE, von Delft F, Weigelt J, Edwards A, Arrowsmith C, Sundstrom M, Doyle D, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTP-binding protein Di-Ras1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 199 amino acids
Theoretical weight: 22.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95057 (Residues: 1-198; Coverage: 100%)
Gene names: DIRAS1, GBTS1, RIG
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand GDP 4 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 64.053Å b: 94.031Å c: 61.214Å
α: 90° β: 89.98° γ: 90°
R-values:
R R work R free
0.161 0.16 0.208
Expression system: Escherichia coli

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