› 2gjd

X-ray diffraction
1.75Å resolution

Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress

Released:
DOI: 10.2210/pdb2gjd/pdb
PDB entry 2gjd coloured by chain, front view.
PDB entry 2gjd coloured by chain, side view.
PDB entry 2gjd coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress.
van Waardenburg RC, Duda DM, Lancaster CS, Schulman BA, Bjornsti MA
Mol Cell Biol 26 4958-69 (2006)
PMID: 16782883

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156251 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SUMO-conjugating enzyme UBC9 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 157 amino acids
Theoretical weight: 17.94 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P50623 (Residues: 1-157; Coverage: 100%)
Gene names: UBC9, YDL064W
Sequence domains: Ubiquitin-conjugating enzyme
Structure domains: Ubiquitin Conjugating Enzyme

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 59.304Å b: 60.141Å c: 95.287Å
α: 90° β: 105.01° γ: 90°
R-values:
R R work R free
0.23 0.21 0.23
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions.
Bjornsti et al. (2019)
1 more

4 mentions without citation

Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction.
Capili et al. (2007)
3 more