› 2gkt

X-ray diffraction
1.23Å resolution

Crystal structure of the P14'-Ala32 variant of the N-terminally truncated OMTKY3-del(1-5)

Released:
DOI: 10.2210/pdb2gkt/pdb
PDB entry 2gkt coloured by chain, front view.
PDB entry 2gkt coloured by chain, side view.
PDB entry 2gkt coloured by chain, top view.
Source organism: Meleagris gallopavo
Primary publication:
Structural insights into the non-additivity effects in the sequence-to-reactivity algorithm for serine peptidases and their inhibitors.
Lee TW, Qasim MA, Laskowski M, James MN
J Mol Biol 367 527-46 (2007)
PMID: 17266986

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159381 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ovomucoid Chain: I
Molecule details ›
Chain: I
Length: 51 amino acids
Theoretical weight: 5.6 KDa
Source organism: Meleagris gallopavo
Expression system: Escherichia coli
UniProt:
  • Canonical: P68390 (Residues: 135-185; Coverage: 28%)
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 23.049Å b: 34.692Å c: 25.795Å
α: 90° β: 97.3° γ: 90°
R-values:
R R work R free
0.132 0.13 0.151
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Non-Canonical Amino Acids in Analyses of Protease Structure and Function.
Goettig et al. (2023)
4 other articles

1 mention without citation

TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections.
Shen et al. (2017)