› 2grc

X-ray diffraction
1.5Å resolution

1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex

Released:
DOI: 10.2210/pdb2grc/pdb
PDB entry 2grc coloured by chain, front view.
PDB entry 2grc coloured by chain, side view.
PDB entry 2grc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Singh M, Popowicz GM, Krajewski M, Holak TA
Chembiochem 8 1308-16 (2007)
PMID: 17582821

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156354 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription activator BRG1 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 15.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51532 (Residues: 1448-1575; Coverage: 8%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21
Unit cell:
a: 29.86Å b: 30.33Å c: 66.82Å
α: 90° β: 90.28° γ: 90°
R-values:
R R work R free
0.25 0.242 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.
Fujisawa et al. (2017)
17 more

15 mentions without citation

Polybromo-1: the chromatin targeting subunit of the PBAF complex.
Thompson M. (2009)
14 more