› 2gse

X-ray diffraction
2.4Å resolution

Crystal Structure of Human Dihydropyrimidinease-like 2

Released:
DOI: 10.2210/pdb2gse/pdb
PDB entry 2gse coloured by chain, front view.
PDB entry 2gse coloured by chain, side view.
PDB entry 2gse coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human collapsin response mediator protein 2, a regulator of axonal growth.
Stenmark P, Ogg D, Flodin S, Flores A, Kotenyova T, Nyman T, Nordlund P, Kursula P
J Neurochem 101 906-17 (2007)
PMID: 17250651

Function and Biology Details

Reaction catalysed: 
5,6-dihydrouracil + H(2)O = 3-ureidopropanoate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172510 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropyrimidinase-related protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 501 amino acids
Theoretical weight: 55.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16555 (Residues: 13-490; Coverage: 84%)
Gene names: CRMP2, DPYSL2, ULIP2
Sequence domains: Amidohydrolase family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 86.4Å b: 126.1Å c: 102.9Å
α: 90° β: 113° γ: 90°
R-values:
R R work R free
0.173 0.169 0.245
Expression system: Escherichia coli BL21(DE3)

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Citations

8 review citations

Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species.
Miki et al. (2012)
7 more

19 mentions without citation

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.
Brittain et al. (2009)
18 more