› 2hau

X-ray diffraction
2.7Å resolution

Apo-Human Serum Transferrin (Non-Glycosylated)

Released:
DOI: 10.2210/pdb2hau/pdb
PDB entry 2hau coloured by chain, front view.
PDB entry 2hau coloured by chain, side view.
PDB entry 2hau coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding.
Wally J, Halbrooks PJ, Vonrhein C, Rould MA, Everse SJ, Mason AB, Buchanan SK
J Biol Chem 281 24934-44 (2006)
PMID: 16793765

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 676 amino acids
Theoretical weight: 75.4 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: P02787 (Residues: 23-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand CIT 4 x CIT
Ligand GOL 2 x GOL
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25, NSLS BEAMLINE X26C, null
Spacegroup: P212121
Unit cell:
a: 87.996Å b: 102.159Å c: 197.044Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.273 0.324
Expression system: Mesocricetus auratus

Quick links

Citations

15 review citations

Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters.
Strohl WR. (2015)
14 more

18 mentions without citation

Transferrin-mediated cellular iron delivery.
Luck et al. (2012)
17 more