› 2hcc

Solution NMR

SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb2hcc/pdb
PDB entry 2hcc coloured by chain, ensemble of 30 models, front view.
PDB entry 2hcc coloured by chain, ensemble of 30 models, side view.
PDB entry 2hcc coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype.
Sticht H, Escher SE, Schweimer K, Forssmann WG, Rösch P, Adermann K
Biochemistry 38 5995-6002 (1999)
PMID: 10320325

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172547 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CCL15(25-92) Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.22 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q16663 (Residues: 48-113; Coverage: 72%)
Gene names: CCL15, MIP5, NCC3, SCYA15
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Structure, function, and inhibition of chemokines.
Fernandez et al. (2002)
1 more

7 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
6 more