› 2he9

X-ray diffraction
2Å resolution

Structure of the peptidylprolyl isomerase domain of the human NK-tumour recognition protein

Released:
DOI: 10.2210/pdb2he9/pdb
PDB entry 2he9 coloured by chain, front view.
PDB entry 2he9 coloured by chain, side view.
PDB entry 2he9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S
PLoS Biol 8 e1000439 (2010)
PMID: 20676357

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NK-tumor recognition protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 21.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30414 (Residues: 7-179; Coverage: 12%)
Gene name: NKTR
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 64.753Å b: 72.786Å c: 73.014Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.149 0.146 0.198
Expression system: Escherichia coli BL21(DE3)

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Citations

37 review citations

Host Factors in Coronavirus Replication.
de Wilde et al. (2018)
36 more

2 mentions without citation

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
Davis et al. (2010)
1 more