› 2hhb

X-ray diffraction
1.74Å resolution

THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb2hhb/pdb
PDB entry 2hhb coloured by chain, front view.
PDB entry 2hhb coloured by chain, side view.
PDB entry 2hhb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human deoxyhaemoglobin at 1.74 A resolution.
Fermi G, Perutz MF, Shaanan B, Fourme R
J Mol Biol 175 159-74 (1984)
PMID: 6726807

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 4 x HEM
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 63.15Å b: 83.59Å c: 53.8Å
α: 90° β: 99.34° γ: 90°
R-values:
R R work R free
0.16 0.16 not available

Quick links

Citations

30 review citations

The origin of protein interactions and allostery in colocalization.
Kuriyan et al. (2007)
29 more

58 mentions without citation

Allostery: absence of a change in shape does not imply that allostery is not at play.
Tsai et al. (2008)
57 more