› 2hkf

X-ray diffraction
2.01Å resolution

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212063 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin Light chain Fab fragment Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Immunoglobulin Heavy chain Fab fragment Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.4 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Carbonic anhydrase 9 Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 926 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16790 (Residues: 83-91; Coverage: 2%)
Gene names: CA9, G250, MN

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P1
Unit cell:
a: 40.388Å b: 43.145Å c: 58.023Å
α: 85.03° β: 88.47° γ: 85.67°
R-values:
R R work R free
0.179 0.176 0.242
Expression system: Not provided

Quick links

Citations

3 review citations

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.
Supuran et al. (2018)
2 more

10 mentions without citation

Revisiting the role of glycosylation in the structure of human IgG Fc.
Borrok et al. (2012)
9 more