› 2hnl

X-ray diffraction
2Å resolution

Structure of the prostaglandin D synthase from the parasitic nematode Onchocerca volvulus

Released:
DOI: 10.2210/pdb2hnl/pdb
PDB entry 2hnl coloured by chain, front view.
PDB entry 2hnl coloured by chain, side view.
PDB entry 2hnl coloured by chain, top view.
Source organism: Onchocerca volvulus
Primary publication:
Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus.
Perbandt M, Höppner J, Burmeister C, Lüersen K, Betzel C, Liebau E
J Mol Biol 377 501-11 (2008)
PMID: 18258257

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155471 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 225 amino acids
Theoretical weight: 25.72 KDa
Source organism: Onchocerca volvulus
Expression system: Escherichia coli
UniProt:
  • Canonical: P46434 (Residues: 11-235; Coverage: 96%)
Gene names: GST1, GSTA
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 2 x GSH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P212121
Unit cell:
a: 50.783Å b: 90.995Å c: 106.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.234
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance.
Choe et al. (2012)
3 more

3 mentions without citation

Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis.
Kwofie et al. (2021)
2 more