› 2hqj

X-ray diffraction
2Å resolution

Cyclophilin from Leishmania major

Released:
DOI: 10.2210/pdb2hqj/pdb
PDB entry 2hqj coloured by chain, front view.
PDB entry 2hqj coloured by chain, side view.
PDB entry 2hqj coloured by chain, top view.
Source organism: Leishmania major
Entry authors: Arakaki TL, Merritt EA, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase Chain: A
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 19.47 KDa
Source organism: Leishmania major
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4QBH1 (Residues: 22-199; Coverage: 60%)
Gene names: CYP11, LMJF_23_0050
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 45.865Å b: 63.511Å c: 66.295Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.239
Expression system: Escherichia coli

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