› 2hu4

X-ray diffraction
2.5Å resolution

N1 neuraminidase in complex with oseltamivir 2

Released:
DOI: 10.2210/pdb2hu4/pdb
PDB entry 2hu4 coloured by chain, front view.
PDB entry 2hu4 coloured by chain, side view.
PDB entry 2hu4 coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.
Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ
Nature 443 45-9 (2006)
PMID: 16915235

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 387 amino acids
Theoretical weight: 42.43 KDa
Source organism: Influenza A virus
UniProt:
  • Canonical: Q6DPL2 (Residues: 63-449; Coverage: 86%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

1 bound ligand:
Ligand G39 8 x G39
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 201.06Å b: 201.24Å c: 211.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.273

Quick links

Citations

71 review citations

Avian influenza virus (H5N1): a threat to human health.
Peiris et al. (2007)
70 more

59 mentions without citation

Dissecting conformational contributions to glycosidase catalysis and inhibition.
Speciale et al. (2014)
58 more