› 2hz6

X-ray diffraction
3.1Å resolution

The crystal structure of human IRE1-alpha luminal domain

Released:
DOI: 10.2210/pdb2hz6/pdb
PDB entry 2hz6 coloured by chain, front view.
PDB entry 2hz6 coloured by chain, side view.
PDB entry 2hz6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.
Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, Kaufman RJ
Proc Natl Acad Sci U S A 103 14343-8 (2006)
PMID: 16973740

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase/endoribonuclease IRE1 Chain: A
Molecule details ›
Chain: A
Length: 369 amino acids
Theoretical weight: 41.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75460 (Residues: 23-390; Coverage: 38%)
Gene names: ERN1, IRE1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P6522
Unit cell:
a: 185.01Å b: 185.01Å c: 67.69Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.268 0.268 0.316
Expression system: Escherichia coli

Quick links

Citations

83 review citations

Signal integration in the endoplasmic reticulum unfolded protein response.
Ron et al. (2007)
82 more

18 mentions without citation

Endoplasmic reticulum stress sensing in the unfolded protein response.
Gardner et al. (2013)
17 more