› 2hzd

Solution NMR

NMR structure of the DNA-binding TEA domain and insights into TEF-1 function

Released:
DOI: 10.2210/pdb2hzd/pdb
PDB entry 2hzd coloured by chain, ensemble of 25 models, front view.
PDB entry 2hzd coloured by chain, ensemble of 25 models, side view.
PDB entry 2hzd coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain.
Anbanandam A, Albarado DC, Nguyen CT, Halder G, Gao X, Veeraraghavan S
Proc Natl Acad Sci U S A 103 17225-30 (2006)
PMID: 17085591

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-1 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28347 (Residues: 27-104; Coverage: 18%)
Gene names: TCF13, TEAD1, TEF1
Sequence domains: TEA/ATTS domain
Structure domains: TEA/ATTS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

24 review citations

The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway.
Hong et al. (2012)
23 more

6 mentions without citation

An evolutionary, structural and functional overview of the mammalian TEAD1 and TEAD2 transcription factors.
Landin-Malt et al. (2016)
5 more